Driven by people’s increasing awareness of living standard along with the development of logistics industry, the scale of China cold chain logistics market has enlarged continually, which has reached 378 billion RMB in 2019, and is expected to reach 485 billion RMB in 2020. At the same time, the number of cold chain logistics enterprises in China has increased constantly, which has reached the number of 1832 in 2019. However, there is a problem of uneven distribution, as 32.3% of the enterprises are located in the Eastern China. So far, there are two main product lines for the application of cold chain logistics, which are food and pharmaceuticals. As the data of iiMedia Research showed, the scale of China fresh food e-commerce market transaction is expected to be over 260 billion RMB, while the market scale of China pharmaceutical logistics is expected to be 3800 billion RMB in 2020, and other new product lines are also expected to be explored in the future, so the market potential of cold chain logistics is substantial. To face with the demand exposure of delivery under the policy of stay home quarantine within the “COVID-19” period, the cold chain logistics enterprises improved their delivery efficiency and customers’ service experience by expanding their delivery network, increasing the vehicles and storage resources, as well as further the application of information technology.